Evidence-based education on telomeres, telomerase, cellular health, and longevity science. Independent research summaries reviewed by qualified scientists.
Telomeres are repetitive nucleotide sequences at each end of a chromosome. They protect the end of the chromosome from deterioration or from fusion with neighboring chromosomes during cell division.
With each cell division, telomeres shorten slightly. When they reach a critical length, the cell enters senescence—a state of growth arrest. This process is one of the primary hallmarks of aging.
Curated summaries of significant studies in telomere biology, cellular senescence, and longevity science. Each summary is independently reviewed by our Scientific Advisory Board.
A comprehensive meta-analysis examining the association between leukocyte telomere length and all-cause mortality across 25 prospective cohort studies.
Long-term dietary, exercise, and stress management intervention demonstrates sustained increases in telomerase activity in peripheral blood mononuclear cells.
An in-depth review of senolytic and senomorphic strategies, evaluating preclinical evidence and ongoing clinical trials targeting the senescence-associated secretory phenotype (SASP).
First longitudinal study to directly compare first-generation and third-generation epigenetic clocks with leukocyte telomere length trajectories over 15 years.
Mechanistic study elucidating the bidirectional relationship between mitochondrial health and telomere integrity in human fibroblast models.
Independent validation of a multi-modal biological age estimator integrating telomere length, DNA methylation, and proteomic markers in 8,500 participants.
Explore the fundamental mechanisms of aging through our curated educational modules. Each topic is reviewed for scientific accuracy and updated quarterly.
Structure, function, and measurement of chromosome end-caps. Explore the molecular biology of telomere maintenance mechanisms.
The irreversible cell-cycle arrest state, its triggers, and the senescence-associated secretory phenotype (SASP).
Mechanisms maintaining genomic integrity including homologous recombination, NHEJ, and base excision repair pathways.
Energy metabolism, mitochondrial dynamics, mitophagy, and the role of mitochondrial dysfunction in aging phenotypes.
Chronic low-grade inflammation as a driver of age-related decline. Cytokine networks and systemic inflammatory markers.
Epigenetic clocks, telomere-based estimators, proteomic signatures, and composite biomarker approaches to quantifying biological aging.
DNA methylation patterns, histone modifications, chromatin remodeling, and the epigenetic clock hypothesis of aging.
All content published on TELOGENIS.org is designed to undergo independent scientific review by a qualified advisory board before publication. Board positions are currently open for qualified applicants.
Newly published studies, database additions, and editorial analyses from the TELOGENIS editorial team.
Randomized, placebo-controlled trial in 586 companion dogs demonstrates modest but significant improvement in cardiac function parameters.
Editorial analysis examining reproducibility concerns in high-profile NAD+ precursor supplementation studies and the distinction between correlation and causation.
Interim results from the CLEARANCE trial evaluating dasatinib + quercetin in participants with diabetic nephropathy and elevated senescence markers.
Large cohort analysis (n=8,400) reveals a non-linear dose-response curve, with diminishing returns above 150 minutes of moderate-intensity exercise weekly.