Telomere Length and Mortality: A Systematic Review and Meta-Analysis of 90,000 Participants
A comprehensive meta-analysis examining the association between leukocyte telomere length and all-cause mortality across 25 prospective cohort studies.
Lifestyle Intervention and Telomerase Activity: A 5-Year Follow-Up Randomized Controlled Trial
Long-term dietary, exercise, and stress management intervention demonstrates sustained increases in telomerase activity in peripheral blood mononuclear cells.
Cellular Senescence as a Therapeutic Target: From Mechanisms to Clinical Translation
An in-depth review of senolytic and senomorphic strategies, evaluating preclinical evidence and ongoing clinical trials targeting the senescence-associated secretory phenotype (SASP).
Correlation Between Epigenetic Clocks and Telomere Length in a Longitudinal Cohort of 2,400 Adults
First longitudinal study to directly compare first-generation and third-generation epigenetic clocks with leukocyte telomere length trajectories over 15 years.
Mitochondrial Dysfunction Induces Telomere Attrition Through ROS-Dependent DNA Damage Response
Mechanistic study elucidating the bidirectional relationship between mitochondrial health and telomere integrity in human fibroblast models.
Validation of a Composite Biological Age Biomarker Panel in a Multi-Ethnic Cohort
Independent validation of a multi-modal biological age estimator integrating telomere length, DNA methylation, and proteomic markers in 8,500 participants.